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Parkinson's disease and Alzheimer's disease as disorders of the isodendritic core
BMJ (Clinical Research Edition)
Parkinson's disease and Alzheimer's disease may represent two parts of a spectrum of disease characterised by a primary loss of cells of the isodendritic core. Secondary cell loss from the striatum and cerebral cortex therefore occurs as a consequence of the loss of ascending projections from the isodendritic cells. The anatomy of this system should provide a unique opportunity for therapeutic intervention. Neurotransmitter replacement treatment may be provided either by enhancing transmitterdoi:10.1136/bmj.283.6306.1588 fatcat:gx7rjdqhnrcppp7r4i7njnh2iu