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The chemical profile of Myrica rubra (a native species in China) leaf extract was investigated by UPLC-PDA-HRMS, and the neuroprotective activity of two characteristic constituents, myricanol and myricetrin, was evaluated with N2a cells using H 2 O 2 -inducedoxidative challenge through a series of methods, e.g., MTT assay, ROS assay and [Ca 2+ ]i assay. Among the 188 constituents detected in the extract of Myrica rubra leaf, 116 were identified definitely or tentatively by the comprehensivedoi:10.3390/molecules22071226 pmid:28737731 fatcat:gy6qpxiv25gltb4vwzngeeov4q