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Objective: In generalized anxiety disorder (GAD), abnormal top-down control from prefrontal cortex (PFC) to amygdala is a widely accepted hypothesis through which "emotional dysregulation model" may be explained. However, whether and how the PFC directly exerted abnormal top-down control on amygdala remained largely unknown. We aim to investigate the amygdala-based effective connectivity by using Granger causality analysis (GCA). Methods: Thirty-five drug-naive patients with GAD and thirty-sixdoi:10.1101/573634 fatcat:v2youfi7lfgqhlchcrbxkeiwkq