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A conserved mechanism regulates reversible amyloids via pH-sensing regions
Amyloids were long viewed as irreversible, pathological aggregates, often associated with neurodegenerative diseases. However, recent insights challenge this view, providing evidence that reversible amyloids can form upon stress conditions and fulfil crucial cellular functions. Yet, the molecular mechanisms regulating functional amyloids and the differences to their pathological counterparts remain poorly understood. Here we investigate the conserved principles of amyloid reversibility bydoi:10.1101/2022.03.21.484600 fatcat:t6zzn7gtinfmlbfqtsdz5v6gsq