KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUM

M. S VEENA, M. K PRASHANTH, K YOGESH KUMAR, H. B MURALIDHARA, Y ARTHOBA NAYAKA
2015 Journal of the Chilean Chemical Society (Print)  
This spectroscopic study presents the kinetics and degradation pathways of oxidation of amoxicillin (AMOX) by chloramines-T (CAT) in acidic medium at a constant ionic strength of 0.105 mol dm -3 at 298 K. Reaction between AMOX and CAT in acidic medium exhibits 1:1 stoichiometry (AMOX:CAT). The reaction is of a first-order in both [CAT] and [AMOX]. The order with respect to acid concentration was fractional. The effects of added products, ionic strength and dielectric constant have been studied.
more » ... The main oxidation product of AMOX was identified by IR, 1 H NMR and mass spectra. The reaction constants involved in the different steps of the mechanisms were calculated. Activation parameters with respect to slow step of the mechanisms were computed and discussed.
doi:10.4067/s0717-97072015000300019 fatcat:4dkp2boly5crflzhyroa5mivhm