Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat

Siamak Reyhani-Rad, Javad Mahmoudi
2016 Acta Cirurgica Brasileira  
PURPOSE: To investigate the role of adenosine A 2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three weeks as a recovery period, 6-OHDA-induced bradykinesia and balance disturbances were assessed by using beam traversal test 10, 30 and 60 minutes after intraperitoneal injections of the drugs (caffeine, SCH58261). RESULTS: The results showed that
more » ... results showed that 6-OHDA (8 μg/rat, Intra-SNc) induced motor disorders of Parkinson's disease and increased elapsed time in the beam test (p<0.001). Injection of caffeine (30 mg/kg, i.p.) and SCH58261 (2 mg/kg, i.p.) attenuated elapsed time on beam (p<0.01 and p<0.001). We showed that acute administration of caffeine and SCH 58261 can improve the 6-OHDA-induced bradykinesia and motor disturbance. CONCLUSION: Adenosine A 2A R antagonists improve 6-OHDA-motor deficit and this effect seems to be mediated by the inhibition of A 2A presynaptic receptors in substantia nigra pars compacta.
doi:10.1590/s0102-865020160020000008 pmid:26959623 fatcat:gfxjttk7yngz3koclhgon2hzyq