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PURPOSE: To investigate the role of adenosine A 2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three weeks as a recovery period, 6-OHDA-induced bradykinesia and balance disturbances were assessed by using beam traversal test 10, 30 and 60 minutes after intraperitoneal injections of the drugs (caffeine, SCH58261). RESULTS: The results showed thatdoi:10.1590/s0102-865020160020000008 pmid:26959623 fatcat:gfxjttk7yngz3koclhgon2hzyq