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Salmonella expresses foreign genes during infection by degrading their silencer
2020
Proceedings of the National Academy of Sciences of the United States of America
The heat-stable nucleoid structuring (H-NS, also referred to as histone-like nucleoid structuring) protein silences transcription of foreign genes in a variety of Gram-negative bacterial species. To take advantage of the products encoded in foreign genes, bacteria must overcome the silencing effects of H-NS. Because H-NS amounts are believed to remain constant, overcoming gene silencing has largely been ascribed to proteins that outcompete H-NS for binding to AT-rich foreign DNA. However, we
doi:10.1073/pnas.1912808117
pmid:32209674
fatcat:ansgbquyl5gvfkmk7cwiphjioy