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Synthesis, characterization, release kinetics, pharmacological screening and in-silico adme prediction of mutual prodrugs of aceclofenac
2014
Journal of Chemical and Pharmaceutical Research
unpublished
Mutual Prodrugs of some non-steroidal anti-inflammatory agent NSAID i.e. Aceclofenac with Salicylamide, Thymol and Glucosamine, were synthesized with the aim of improving the therapeutic index through prevention of gastrointestinal implications and to check the efficiency of release of the parent drug in presence of spacer as well as without spacer. These mutual prodrugs were synthesized by direct condensation method using dicyclohexylcarbodiimide as a coupling agent and alanine as spacer. The
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