IDDF2020-ABS-0113 Budding association between gut microbiome in the development of Myasthenia Gravis

Learn-Han Lee, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Hooi-Leng Ser, Vengadesh Letchumanan
2020 Abstracts   unpublished
studies were screened and refined by the inclusion and exclusion criteria. Studies involving gut microbiome and CU were considered for inclusion. Irrelevant articles based on title/ abstract level, case reports, conference abstracts and other studies with no experimental intervention (reviews, book, commentaries) were excluded. Results Three studies were eligible for final qualitative analysis, with a total of 100 participants. Research findings have shown that CU patients have a significant
more » ... ve a significant decrease in abundance of Firmicutes (Lactobacillus; Faecalibacterium prausnitzii), Actinobacteria (Bifidobacterium), Bacteroidetes (Bacteroides fragilis, Bacteroides plebeius), whilst an increase in abundance of Proteobacteria. The research suggested that increased abundance of Proteobacteria might enhance the permeability of intestinal mucus inner layer and enable bacterial infiltration, causing inflammation of epithelium and impairment of gut barrier function which leads to the development of inflammatory skin diseases. Conclusions As a summary, this outcome provides a preliminary understanding of microbial composition in CU patients ( figure 1 ). This offers a new avenue of research for potential CU treatment via maintaining gut health. Abstract IDDF2020-ABS-0112 Figure 1 Altered gut microbiome is associated with development of chronic urticaria Abstract IDDF2020-ABS-0113 Figure 1 Abstracts Gut 2020;69(Suppl 2):A1-A95 A17 on December 20, 2020 by guest. Protected by copyright. Abstract IDDF2020-ABS-0115 Figure 1 Potential importance of gut microbiome in osteoporosis Abstracts A18 Gut 2020;69(Suppl 2):A1-A95
doi:10.1136/gutjnl-2020-iddf.23 fatcat:hxoaz2vfwrdwrf6zdk7lsi5k2e