BACKGROUND In clinical practice, disorders of thyroid are common worldwide and incidence of which varies with geographical as well as nutritional factors. About twelve percent of Indian adults have palpable goitre. Nowadays, thyroidectomy is a routine surgical procedure offering the chances of cure to many patients having goitre. Aim of the study is to find out the common indications of thyroidectomy in our centre and to study the frequency and histopathological spectrum of follicular cell

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... ed lesions in thyroidectomy specimens. MATERIALS AND METHODS It is a record-based retrospective study conducted in a tertiary care teaching centre in central Kerala. All thyroidectomy specimens received in the Department of Pathology in our centre from January 2011 to December 2015 for histopathological study were included in this study. Lesions involving ectopic thyroid tissue were excluded. Data including patient's age, sex, type of surgery done and histopathological diagnosis were collected from the records and analysed by SPSS package 16.0. RESULTS The commonest indication for thyroidectomy in all age group was follicular cell derived lesions of thyroid. Frequency of follicular cell derived lesions was 99.2% among thyroid specimens. Most common follicular cell derived lesion was multinodular colloid goitre. Papillary carcinoma was the commonest follicular cell derived malignant lesion of thyroid. Peak incidence of both neoplastic and non-neoplastic category of follicular cell derived lesions was noted in the age group of 40-49 years. Frequency of follicular cell derived lesions was significantly higher in females than males. CONCLUSION Current study showed comparatively higher prevalence rate of thyroid lesions and the peak incidence of follicular cell derived lesions in the age group of 40-49 years. This difference may be due to the influence of nutritional and environmental factors, so more observations and studies are warranted in this aspect.