Effect of bilateral adrenalectomy on VIP receptor/effector system in rat intestinal epithelial cells

M. D. Fern�ndez-Moreno, I. Carrero, E. Arilla, J. C. Prieto
1990 Bioscience Reports  
The number of vasoactive intestinal peptide (VIP) receptors and the efficiency of VIP in the stimulation of cyclic AMP accumulation in rat jejunal epithelial cells increased after bilateral adrenalectomy. However, this condition increased neither receptor affinity nor VIP potency. In addition, jejunal VIP levels followed a parallel increase. These changes reversed to control conditions after glucocorticoid replacement with dexamethasone indicating that adrenalectomy modifies the intestinal VIP
more » ... the intestinal VIP receptor/effector system and suggest a relationship between corticosteroids and VIP in the functions of intestinal epithelium.
doi:10.1007/bf01116575 pmid:2162701 fatcat:hiijbyzyfrbyzjrw5dwwaxuzfi