Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential

Ana Carolina Oliveira Bretas, Thiago Belarmino de Souza, Beatriz Borelli, Suzana Johan, Ricardo José Alves
2020 Brazilian Journal of Pharmaceutical Sciences  
Systemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cell wall, is absent in mammals and this makes it an excellent target for the
more » ... of new antifungal agents. Papulacandins are a family of natural antifungal agents targeting (1,3)-β-D-glucan synthase. In this study we describe the synthesis and biological evaluation of two new Papulacandin analogs as potential (1,3)-β-D-glucan synthase inhibitors.
doi:10.1590/s2175-97902019000417652 fatcat:kkzowxicbra3tiymdax4mgufvu