実験用ラット肝障害時における血清酵素および凝固・線溶系の変動
Changes in serum enzyme activities and in the coagulation-fibrinolytic system in experimental hepatic injury

Satoshi UNAKAMI, Yoshifumi TANIMOTO
1981 Blood & Vessel  
Changes in serum enzyme activities and in the coagulation-fibrinolytic system in drug-induced hepatic injury were studied in rats. Hepatic injury was induced in rats by single dose administration of carbon tetrachloride (CCl4: 200 or 600 p1/kg), D-galactosamine (D-Gal: 150 or 450 mg/kg) and a-naphthyl isothiocyanate (ANIT: 60 or 180 mg/mg). All determinations were performed at 1 to 48 hours after administration of CC14 or D-Gal, and at 7 to 72 hours after administration of ANIT. The results
more » ... IT. The results were follows. In the rats treated with D-Gal, the activities of GPT and GOT in the serum were found to correlate closely with the hepaplastin test (HPT) and prothrombin time (PT) results. In rats dosed with CC14, serum enzyme activities clearly elevated at 1 hour, while the serum GPT, GOT, and LDH activities maximized at 24 hours. On the other hand, HPT values, activated partial thromboplastine time (APTT) values and antithrombin III (AT III) levels were slower to change and earlier to recover than the serum enzyme activities. Thus, there appeared to be almost no relationship between serum enzyme activities and coagulation-fibrinolytic activities. In rats dosed with ANIT, No regular tendency was observed in the variation of the coagulation-fibrinolytic system in comparison with serum enzyme activity variation. These results suggested that the degree and patterns of variation in serum enzyme activity and in the coagulation-fibrinolytic system differed considerably with differences in the type of hepatic injuries.
doi:10.2491/jjsth1970.12.375 fatcat:jtbg6iokirh7xfd4ovxjouqkl4