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There is a growing interest in continuous processing of the biopharmaceutical industry. However, the technology transfer from traditional batch-based processes is considered a challenge as protocol and tools still remain to be established for their usage at the manufacturing scale. Here, we present a model-based approach to design optimized perfusion cultures of Chinese Hamster Ovary cells using only the knowledge captured during small-scale fed-batch experiments. The novelty of the proposeddoi:10.3389/fbioe.2022.948905 pmid:36072286 pmcid:PMC9443430 fatcat:qdbuevx5mvg2lhzpw35e2ypiw4