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Topics in Local Anesthetics [Working Title]
Local anesthetics are basically weak bases whose structure consists of an aromatic half connected to a substituted amine through an ester amide linkage. The pKa values of local anesthetics are close to physiological pH, both protonated and unprotonated forms are present. The individual structures confer different physiochemical and clinical characteristics. Potency is correlated to lipid solubility in vitro, but less so in vivo. The duration of action is associated with the extent of proteindoi:10.5772/intechopen.91700 fatcat:htruibba6bebnh4z4zjrw37vay