Treatment of Typhoid Fever in Children: Comparison of Efficacy of Ciprofloxacin with Ceftriaxone

2016 European Scientific Journal  
Objective: To compare the clinical efficacy of ciprofloxacin vs ceftriaxone in terms of the proportion of children becoming afebrile in 96 hours. Study Design: Randomized controlled design study. Place and Duration of Study: Department of Pediatrics, Holy Family Hospital, Rawalpindi from March 2010 to September 2010. Methodology: 88 children who fulfilled the clinical criteria of having typhoid fever were included in the study. They came to the indoor and outdoor of the department. 44 patients
more » ... ere treated with injectable ciprofloxacin, while 44 were treated with injectable ceftriaxone. Results: The study included 88 patients with febrile illness who were suspected of having typhoid fever. The mean age was 8.3±1.94 years and 41 (46.6%) were males. The mean weight was 24.7±6.3 kg. Only 15 (17%) used boiled water as a routine. 68 (77.3%) children in total became afebrile within 96 hours and 20 (22.7%) failed to become afebrile in 96 hours. In the ciprofloxacin group, 25 (56.8%) patients became afebrile in 96 hours and 19 (43.1%) failed to become afebrile in 96 hours. In the ceftriaxone group, 43 (97.7%) patients became afebrile in 96 hours and 1 (2.3%) failed to become afebrile in 96 hours. The proportion of patients becoming afebrile within 96 hours was significantly higher in the ceftriaxone group as compared to the ciprofloxacin group, p= 0.00. Conclusion: Ceftriaxone is more effective in children with typhoid fever in terms of greater proportion of children becoming afebrile in 96 hours.
doi:10.19044/esj.2016.v12n6p346 fatcat:ouvgr5njxjcfjomjsuhlk5bnfu