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Single-cell gene regulatory network analysis reveals potential mechanisms of action of antimalarials against SARS-CoV-2
[post]
2020
unpublished
The efficiency of antimalarials, chloroquine (CQ) and hydroxychloroquine (HCQ), in the prevention and treatment of coronavirus disease 2019 (COVID-19) is under intense debate. The mechanisms of action of antimalarials against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been fully elucidated. Here, we applied a network-based comparative analysis, implanted in our machine learning workflow—scTenifoldNet, to scRNA-seq data from COVID-19 patients with different levels of
doi:10.31219/osf.io/va7ux
fatcat:dvbczifmbnhlvktgz3x35dn6sq