Issue:2 Citation: Fanantenanirainy Randimbivololona et al. Ijppr

Solofoniaina Andriamalala, Jean-François Rajaonarison, Patricia Randrianavony, Nat Quansah, Fanantenanirainy Randimbivololona
2018 Human   unpublished
Centella asiatica is a perennial herbaceous creeper of local and global health importance. Comparative studies of the leaves and whole plant decoctions have been carried out to investigate their anti-gastric ulcer property, based on their anti-secretory as well as their gastric-mucous-protecting capabilities. The results obtained with absolute ethanol aggression showed that the two decoctions protect the gastric mucosa. The area of hyperemia in the animals treated with both decoctions was
more » ... ecoctions was inferior compared to the control animals. It was 139.20 ± 1.20 mm2 for the control group, versus 11.02 ± 0.057 and 10.86 ± 0.030 mm2 for the animals which received 200 mg/kg of leaves and whole plant decoctions respectively. After pylorus ligation, the pH of the gastric content of the control group animals is inferior to the treated groups. It was 3.20 ± 0.21 versus 6.30 ± 0.10 and 6.32 ± 0.10 for the animals treated with 200 mg/kg of the leaves and whole plant decoctions respectively. The results show that decoctions of the leaves and that of the whole plant of C. asiatica protect the gastric mucosa of the rats against the ulcerogenic effect of absolute ethanol and decreases gastric acidity after pylorus ligation.