Amphibian skin extracts as source of bioactive multi-target agents against different pathways of Alzheimer's disease

Roque Spinelli, Florencia María Aimaretti, Javier Alejandro López, Alvaro Sebastián Siano
2019 Figshare  
Natural products represent a rich source of bioactive compounds that have been historically used to obtain substances with great medicinal potential. The skin of anuran amphibians is a rich source of compounds with a wide range of biological activity. Alzheimer's disease (AD) is a complex disease associated with all kind of different pathways, making their simultaneous modulation necessary. Nowadays anti-AD treatments are focused on enzymatic inhibitors. Here in we report the activity of skin
more » ... tracts from nine species from Argentina, belonging to three anuran families, as inhibitors of AChE, BChE and MAO-B enzymes. The extracts also showed antioxidant activities, acting as multi-target on four important pathways of AD.
doi:10.6084/m9.figshare.7929698.v1 fatcat:dgd6jdvclze6fg2afp5ykmcwfm