CD-Search: protein domain annotations on the fly

A. Marchler-Bauer, S. H. Bryant
2004 Nucleic Acids Research  
We describe the Conserved Domain Search service (CD-Search), a web-based tool for the detection of structural and functional domains in protein sequences. CD-Search uses BLAST 1 heuristics to provide a fast, interactive service, and searches a comprehensive collection of domain models. Search results are displayed as domain architecture cartoons and pairwise alignments between the query and domain-model consensus sequences. Search results may be visualized in further detail by embedding the
more » ... y sequence into multiple alignment displays and by mapping onto three-dimensional molecular graphic displays of known structures within the domain family. CD-Search can be accessed at http:// www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi.
doi:10.1093/nar/gkh454 pmid:15215404 pmcid:PMC441592 fatcat:kqqxv7qtwbfx7cwdz2ktmbkvhe