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The studies described in this thesis were performed within GROW-School for Ocology and Development Biology and within CAPHRI School for Public Health and Primary Care. Cover design: Bart Ploemen Layout: Marijke Hendrix Printed by: Datawyse, Universitaire Pers Maastrichtdoi:10.26481/dis.20100616mh fatcat:i5ysk7qnjng6lg7uogdexvgxoa