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Identification of the Proteinase K-resistant Antigen of Orientia tsutsugamushi by Monoclonal Antibodies
Journal of Bacteriology and Virology
Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular bacterium that replicates in the cytosol of host cells. Although several protein antigens have been characterized and cloned, little information exists regarding the polysaccharide antigen of this bacterium. In this study, we characterized two monoclonal antibodies, NT19 and WT14, against the proteinase K-resistant antigen of O. tsutsugamushi. Western blot analysis showed that MAb NT19 and WT14 stronglydoi:10.4167/jbv.2008.38.1.11 fatcat:neje2owmibggzg42dsb6hz56sa