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Topographical Propagation of α-synuclein Pathology in Parkinson's Disease: Phenomenology and Hypothetical Mechanism
Parkinson's disease is an age-related, slowly progressing neurodegenerative disorder characterized by abnormal deposition of aggregated α-synuclein in neuronal cell bodies (Lewy bodies) and neurites (Lewy neurites), as well as in glia. Based on semiquantitative assessment of Lewy pathologies in autopsy samples, a staging system was proposed indicating a highly predictable sequence of pathological progression. This staging system implicates a propagation of α-synuclein aggregation throughout thedoi:10.5607/en.2009.18.1.19 fatcat:kuj5wdf2vvcmrees2c7gwhuzsi