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Circular RNAs in drug resistant tumors
Biomedicine and Pharmacotherapy
Chemotherapy is an effective method to treat patients with advanced malignant tumors. However, tumor cells can develop resistance to multiple drugs during the therapy process, leading to treatment failure. Circular RNAs (circRNAs) are a new class of regulatory RNAs that can regulate endogenous gene expression. Previous studies revealed the diagnostic and prognostic value of circRNAs in malignant cancer and other diseases, but few reports have examined their association with clinical drugdoi:10.1016/j.biopha.2019.109233 pmid:31351436 fatcat:zzfb4o5u6jfs5euy6kjrfesb3e