Circular RNAs in drug resistant tumors

Xin Hua, Yue Sun, Jing Chen, Ying Wu, Jun Sha, Shuhua Han, Xiaoli Zhu
2019 Biomedicine and Pharmacotherapy  
Chemotherapy is an effective method to treat patients with advanced malignant tumors. However, tumor cells can develop resistance to multiple drugs during the therapy process, leading to treatment failure. Circular RNAs (circRNAs) are a new class of regulatory RNAs that can regulate endogenous gene expression. Previous studies revealed the diagnostic and prognostic value of circRNAs in malignant cancer and other diseases, but few reports have examined their association with clinical drug
more » ... nce. In this review, we summarize the up-to-date information regarding the role of circRNAs in the resistance of tumors to chemotherapy and discuss specific regulatory mechanisms. This analysis is expected to provide direction for the prevention and management of drug resistance in tumors.
doi:10.1016/j.biopha.2019.109233 pmid:31351436 fatcat:zzfb4o5u6jfs5euy6kjrfesb3e