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Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice
Journal of Biological Chemistry
Edited by Luke O'Neill PD-L1 (programmed death ligand 1) and PD-L2 are cell-surface glycoproteins that interact with programmed death 1 (PD-1) on T cells to attenuate inflammation. PD-1 signaling has attracted intense interest for its role in a pathophysiological context: suppression of anti-tumor immunity. Similarly, vitamin D signaling has been increasingly investigated for its nonclassical actions in stimulation of innate immunity and suppression of inflammatory responses. Here, we show thatdoi:10.1074/jbc.m117.793885 pmid:29061851 fatcat:dfa2ljgynfakdf4jrnysew4pi4