Comparison of the effect between two doses of vaginal misoprostol in the termination of firsttrimester pregnancy: a double-blinded randomized trial Submit Manuscript | Abstract Background and aim: a higher dose of misoprostol may increase its efficacy on the termination of pregnancy, we compared the impact of 400 µg every 6 hours daily with 800µg daily of vaginal misoprostol for termination of early pregnancy. Methods and materials: in this randomized clinical trial 90 pregnant women with

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... ional age less than 96 days were randomized to receive vaginal misoprostol either the 400µg every 6 hours (group A) or 800µg once a day (group B) for three days, then, success of abortion and complication of these methods were compared with each others. Results: Of 90 recruited women, successful medical abortions occurred in 44 patients, 27 (60%) women in group A and 17 (37%) women in group B. The difference of success was significant (P=0.043). The severity of vaginal bleeding was significantly lower in group A(p=0.004), but diarrhea and fever were more common in group A. No other serious complications such as massive hemorrhage were found in both groups. Conclusion: lower but multiple doses of vaginal misoprostol (400 mcg every 6hrs) was more effective than 800mcg daily in the medical termination of first-trimester pregnancy. Citation : Farzaneh D, Khosravi D, Hosseini MS, et al. Comparison of the effect between two doses of vaginal misoprostol in the termination of first-trimester pregnancy: a double-blinded randomized trial. Obstet Gynecol Int J. 2018;9(1): 00311. Comparison of the effect between two doses of vaginal misoprostol in the termination of first-trimester pregnancy: a double-blinded randomized trial 96 Copyright: ©2018 Farzaneh et al. Citation: Farzaneh D, Khosravi D, Hosseini MS, et al. Comparison of the effect between two doses of vaginal misoprostol in the termination of first-trimester pregnancy: a double-blinded randomized trial. Obstet Gynecol Int J. 2018;9(1): 00311. Comparison of the effect between two doses of vaginal misoprostol in the termination of first-trimester pregnancy: a double-blinded randomized trial 98