Internet Archive Scholar

Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi-centre cardiovascular magnetic resonance imaging trial

Felix Mahfoud, Daniel Urban, Desiree Teller, Dominik Linz, Philipp Stawowy, Jan-Hendrik Hassel, Peter Fries, Stephan Dreysse, Ernst Wellnhofer, Günther Schneider, Arno Buecker, Christopher Schneeweis (+6 others)
2014 European Heart Journal  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (336.3 kB)
https://web.archive.org/web/20190305105647/http://pdfs.semanticscholar.org/c886/ea08b7db4a9d7ddece93c66c18c74c0bf44b.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL. The file type is application/pdf.

Aims Sympathetic stimulation induces left ventricular hypertrophy and is associated with increased cardiovascular risk. Catheter-based renal denervation (RDN) has been shown to reduce sympathetic outflow and blood pressure (BP). The present multi-centre study aimed to investigate the effect of RDN on anatomic and functional myocardial parameters, assessed by cardiac magnetic resonance (CMR), in patients with resistant hypertension. Methods and results Cardiac magnetic resonance was performed in
more » ... 72 patients (mean age 66 + 10 years) with resistant hypertension (55 patients underwent RDN, 17 served as controls) at baseline and after 6 months. Clinical data and CMR results were analysed blindly. Renal denervation significantly reduced systolic and diastolic BP by 22/8 mm Hg and left ventricular mass index (LVMI) by 7.1% (46.3 + 13.6 g/m 1.7 vs. 43.0 + 12.6 g/m 1.7 , P , 0.001) without changes in the control group (41.9 + 10.8 g/m 1.7 vs. 42.0 + 9.7 g/m 1.7 , P ¼ 0.653). Ejection fraction (LVEF) in patients with impaired LVEF at baseline (,50%) significantly increased after RDN (43% vs. 50%, P , 0.001). Left ventricular circumferential strain as a surrogate of diastolic function in the subgroup of patients with reduced strain at baseline increased by 21% only in the RDN group (214.8 vs. 217.9; P ¼ 0.001) and not in control patients (215.5 vs. 216.4, P ¼ 0.508). Conclusions Catheter-based RDN significantly reduced BP and LVMI and improved EF and circumferential strain in patients with resistant hypertension, occurring partly BP independently. ---
doi:10.1093/eurheartj/ehu093 pmid:24603307 fatcat:dmkflagqzngg3p46ucpprxttvy
Citation

Felix Mahfoud, Daniel Urban, Desiree Teller, Dominik Linz, Philipp Stawowy, Jan-Hendrik Hassel, Peter Fries, Stephan Dreysse, Ernst Wellnhofer, Günther Schneider, Arno Buecker, Christopher Schneeweis, Adelina Doltra, Markus P. Schlaich, Murray D. Esler, Eckart Fleck, Michael Böhm, Sebastian Kelle. "Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi-centre cardiovascular magnetic resonance imaging trial." European Heart Journal 35.33 (2014) 2224-2231