0.55 points, respectively; group difference, 0.89 points; 95%CI -3.89 to 5.68; p=0.713). Week 52 least squares means for body weight and KOOS pain showed similar results ( Figure 2 ). 4 patients in the intervention and 4 patients in the control groups experienced serious adverse events, and no deaths were observed. Conclusion: In overweight patients with knee OA, an 8-week low-calorie diet intervention significantly reduced body weight and knee pain. Liraglutide treatment added after the

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... ed after the initial diet-induced weight loss provided further weight loss over 1 year but did not reduce knee pain any further compared to placebo.