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Identification of Novel Mutations Controlling Cerebral Cortex Malformations Caused by ENU-Induced Mutagenesis in the Mouse
Sovremennye tehnologii v medicine
The aim of the study is to identify new gene mutations causing cerebral cortex malformations in mice. Materials and Methods. To identify genes causing cerebral cortex malformations, chemical mutagenesis was carried out using N-ethyl-N-nitrosourea as a mutagen. A total of 141 male C3H mice aged 8 weeks were injected with the mutagen in order to induce mutations in spermatogonial stem cells. After a period of sterility, the animals were used in three-generation backcross scheme. Satb2-LacZdoi:10.17691/stm2018.10.3.8 fatcat:ljvrc6gfqzcklosznfzfhgqit4