An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1

R Collman, J W Balliet, S A Gregory, H Friedman, D L Kolson, N Nathanson, A Srinivasan
1992 Journal of Virology  
We isolated and molecularly cloned a human immunodeficiency virus type 1 (HIV-1) strain (89.6) which is unusual because it is both macrophage-tropic and extremely cytopathic in lymphocytes. Moreover, this is the first well-characterized infectious molecularly cloned macrophage-tropic HlV-1 strain derived from peripheral blood. HIV-1 89.6 differs markedly from other macrophage-tropic isolates within the envelope V3 region, which is important in determining cell tropism and cytopathicity. HlV-1
more » ... opathicity. HlV-1 89.6 may thus represent a transitional isolate between noncytopathic macrophage-tropic viruses and cytopathic lymphocyte-tropic viruses.
doi:10.1128/jvi.66.12.7517-7521.1992 fatcat:x4uxtapmjjgrzgrwfuuv3k65xa