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Bovine respiratory syncytial virus lacking the virokinin or with a mutation in furin cleavage site RA(R/K)R109 induces less pulmonary inflammation without impeding the induction of protective immunity in calves
2006
Journal of General Virology
The BRSV fusion (F) protein is cleaved at two furin consensus sequence sites, resulting in the generation of disulphide-linked F1 and F2 subunits and the release of an intervening peptide of 27 amino acids (pep27), which is converted into a biologically active tachykinin (virokinin). The role of the virokinin and the importance of one of the furin cleavage sites, FCS-2 [RA(R/K)R 109 ], in the pathogenesis of BRSV infection and in the subsequent development of immunity was studied in gnotobiotic
doi:10.1099/vir.0.81755-0
pmid:16690931
fatcat:mthqxdfss5hrbml6tlkbk3bhea