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CXCL10 Is an Agonist of the CC Family Chemokine Scavenger Receptor ACKR2/D6
2021
Cancers
Atypical chemokine receptors (ACKRs) are important regulators of chemokine functions. Among them, the atypical chemokine receptor ACKR2 (also known as D6) has long been considered as a scavenger of inflammatory chemokines exclusively from the CC family. In this study, by using highly sensitive β-arrestin recruitment assays based on NanoBiT and NanoBRET technologies, we identified the inflammatory CXC chemokine CXCL10 as a new strong agonist ligand for ACKR2. CXCL10 is known to play an important
doi:10.3390/cancers13051054
pmid:33801414
pmcid:PMC7958614
fatcat:jhd7unbjt5dmvgiiwtcnps4y2q