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Enantioselective Total Synthesis of (+)-Amphirionin-4
2016
Organic Letters
An enantioselective total synthesis of (+)-amphirionin-4 has been accomplished in a convergent manner. The synthesis features an efficient enzymatic lipase resolution to access the tetrahydrofuranol core in optically-active form. The functionalized tetrahydrofuran derivative was synthesized via an oxocarbenium ion-mediated highly diastereoselective syn-allylation reaction. The polyene side chain was synthesized using Stille coupling reactions. Nozaki-Hiyama-Kishi coupling was utilized to
doi:10.1021/acs.orglett.6b00942
pmid:27116318
pmcid:PMC5328589
fatcat:wjzv5srihvf45o7hgzihnj5nq4