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W E used in our study Twenty rats ,divided into two groups .the first group consist of 10 rats considered as a control group, while the second group treated with 0.05 ml\body weight\day of dipyron injected for 30 days duration. The toxic effect of dipyrone was obvious in the different tissue and haematotoxic effects . The histological changes were obvious in the hepatic cell whichof liver were characterized by atrophy ,irregular hepatic cells ,RBC cells in the blood sinusoid. However,the spleendoi:10.21608/ejvs.2020.19551.1126 fatcat:r4rh64arqrcsvlvehlvdhhbi3a