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Improved assay protocol for measurement of ammonia on the Roche Cobas 8000 automated platform
2019
Practical Laboratory Medicine
Ammonia is a metabolite of protein catabolism that, when elevated, may be toxic for tissues, especially for the central nervous system. Elevated ammonia in blood is an indicator and a prognostic factor for hepatic and kidney disease or inherited metabolic disorders in nitrogen metabolism. The accuracy of ammonia determination is influenced by sampling condition, handling, storage and assay itself. Our and other laboratories have been experiencing high frequencies sample error flags while
doi:10.1016/j.plabm.2018.e00115
pmid:30581950
pmcid:PMC6295606
fatcat:gvt43junpffzbibkelx7saps2i