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SigSeeker: a peak-calling ensemble approach for constructing epigenetic signatures
2017
Bioinformatics
Epigenetic data are invaluable when determining the regulatory programs governing a cell. Based on use of next-generation sequencing data for characterizing epigenetic marks and transcription factor binding, numerous peak-calling approaches have been developed to determine sites of genomic significance in these data. Such analyses can produce a large number of false positive predictions, suggesting that sites supported by multiple algorithms provide a stronger foundation for inferring and
doi:10.1093/bioinformatics/btx276
pmid:28449120
pmcid:PMC5860059
fatcat:rwir7clzl5hzxoegxymms42vkm