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Trade-Offs between Speed, Accuracy, and Dissipation in tRNAIle Aminoacylation
[article]
2020
bioRxiv
pre-print
Living systems maintain a high fidelity in key biological processes through kinetic proofreading, a mechanism to preferentially remove incorrect substrates at the cost of energy dissipation and slower speed. Proofreading mechanisms must balance their demand for higher speed, fewer errors, and lower dissipation, but it is unclear how rates of individual reaction steps are evolutionary tuned to balance these needs, especially when multiple proofreading mechanisms are present. Here, using a
doi:10.1101/2020.04.06.027615
fatcat:dkuzopjr5rezrckdg7plj62vvy