The purpose of this study is to develop polystyrene nanoparticles using nanoprecipitation method. Formation of nanoparticles from pre-polymer by nanoprecipitation is a beneficial technique involving the diffusion of polymer phase into dispersion phase. However, selection of solvent /non-solvent couple has intensive influence on nanoprecipitation of specific polymer. In this study the potential of chloroform (CHCl3) and tetrahydrofuran (THF) is explored as the solvent for polystyrene. Effect of

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... ispersion phase; methanol, chloroform, acetone and water have been investigated on nanoprecipitation of polystyrene. It was found that the addition of surfactants enhanced the stability of nanoparticles.Tween-40 has a more pronounced stabilizing effect than Pluronic F-68 on polystyrene nanoparticles in aqueous phase. More stable nanoparticles of polystyrene were obtained in the aqueous medium containing 2-g/L of Tween-40. Interface interaction of mixing phases and surface active agents affect the size and stability of nanoparticles in nanoprecipitation.