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Targeted delivery of small interfering RNA using single-chain variable antibody fragments (scFvs)
2012
Science-Business eXchange
Approach Summary Licensing status Publication and contact information Drug delivery Targeted delivery of small interfering RNA using single-chain variable antibody fragments (scFvs) Studies in mice suggest scFv-mediated delivery of siRNA could help treat cancer. In an orthotopic xenograft mouse model of HER2 + (EGFR2; ERBB2; neu) breast cancer, i.v. injection of a polo-like kinase 1 (PLK1; STPK13) siRNA complexed with an anti-HER2 scFv-protamine fusion protein decreased tumor growth compared
doi:10.1038/scibx.2012.477
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