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Targeted delivery of small interfering RNA using single-chain variable antibody fragments (scFvs)

2012 Science-Business eXchange  

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Approach Summary Licensing status Publication and contact information Drug delivery Targeted delivery of small interfering RNA using single-chain variable antibody fragments (scFvs) Studies in mice suggest scFv-mediated delivery of siRNA could help treat cancer. In an orthotopic xenograft mouse model of HER2 + (EGFR2; ERBB2; neu) breast cancer, i.v. injection of a polo-like kinase 1 (PLK1; STPK13) siRNA complexed with an anti-HER2 scFv-protamine fusion protein decreased tumor growth compared
more » ... h injection of PLK1 siRNA alone. In a xenograft mouse model of metastatic cancer, the complexed siRNA increased survival of animals with HER2 + cancer compared with siRNA or scFv alone. Next steps could include applying the platform to the delivery of additional siRNA therapeutics.
doi:10.1038/scibx.2012.477 fatcat:m62nddypifel7dyioyw7viavye
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"Targeted delivery of small interfering RNA using single-chain variable antibody fragments (scFvs)." Science-Business eXchange 5.18 (2012) 477-477