A simple method for measuring severely reduced glomerular filtration rate

A J White, M Rachalewska, R R Venkannagari
2000 Journal of Nuclear Medicine Technology  
The purpose of this study was to develop a simpler method to measure severely reduced glomerular filtration rate (GFR) for patients with a GFR below 30 mL/min. The GFR was measured in 24 patients using both the 51Cr EDTA slope-intercept method (the conventional method) and 99mTc-DTPA with our proposed simpler GFRn method. The correlation coefficient was 0.92 between the 2 methods, with a slope of 0.97 and an intercept of 2 mL/min. Our simplified method for measuring GFR is accurate for most
more » ... ents with severely reduced GFR. Errors are acceptably small in patients with severely reduced GFR when edema or dehydration are present. If extrarenal (liver) clearance is significant, however, a urine sampling method is required for an accurate GFR measurement.
pmid:11001500 fatcat:cduaoove2fhrpmjauna2j4llzq