Serum Cholesterol in Pentolinium -Treated Arterial Hypertension

HAROLD H. ORVIS, IRENE G. TAMAGNA, JOHN M. EVANS
1958 Circulation  
Serum lipids were serially determined in 11 patients receiving pentolinium therapy to evaluate changes secondary to blood pressure effects. Substantial reduction in total Cholesterol was observed, which in some cases was independent of the hypotensive effect of the drug. Fat absorption, studied in 6 patients, revealed diminished postprandial lipemia in each as' compared to placebo determinations. However, few patients showed appreciable weight change during a year of therapy. The evidence
more » ... ts that the serum lipid changes seeondary to pentolinium administration are due to a qualitative change in fat absorption.
doi:10.1161/01.cir.17.2.176 pmid:13511633 fatcat:6gdo7gp6inhn5joldxux3de7mu