We are presenting 67-year-old female, known to have diabetes for 10 years, not compliance to medication. Presented with 3 weeks history of isolated right lower limb and left thigh pain. Then she started to develop redness and swelling in same areas. She had also History of dry cough for one week. Admitted as a case of necrotizing fasciitis based on clinical laboratory and radiological features. She was treated empirically with vancomycin and meropenem and went for debridement twice.

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... gy and culture showed Cryptococcus neoformans. Investigations were done to rule out other immune system disorders. We started her on high dose intravenous fluconazole. Ten days later she developed multi organ failure and death. As a conclusion, Cryptococcus might affect non-HIV patients regardless of their immune system.