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Perturbation of cellular calcium blocks exit of secretory proteins from the rough endoplasmic reticulum
Journal of Biological Chemistry
In the cultured human hepatoma HepG2, Ca2+ ionophores block secretion of different secretary proteins to different extents, alpha 1-antitrypsin secretion being more sensitive to A23187 and ionomycin than is alpha 1-antichymotrypsin, and albumin secretion the least of the three proteins studied. As judged by subcellular fractionation experiments and by treatment of pulse chase labeled protein with endoglycosidase H, A23187 and ionomycin cause newly made secretory proteins to remain within thepmid:2162823 fatcat:srczu2owbvdmbcw3gfwvvmte2m