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COCO-CL: hierarchical clustering of homology relations based on evolutionary correlations
2006
Computer applications in the biosciences : CABIOS
Motivation: Determining orthology relations among genes across multiple genomes is an important problem in the post-genomic era. Identifying orthologous genes can not only help predict functional annotations for newly sequenced or poorly characterized genomes, but can also help predict new protein-protein interactions. Unfortunately, determining orthology relation through computational methods is not straightforward due to the presence of paralogs. Traditional approaches have relied on pairwise
doi:10.1093/bioinformatics/btl009
pmid:16434444
pmcid:PMC1620014
fatcat:qndlgpbim5de5dahdavqscea7u