Essential phospholipids use in the treatment of drug-induced liver injury in pregnant women

Liudmila K Palgova, Irina V Borisova, Natalia V Zhestkova, Marina A Tarasova
2017 Journal of obstetrics and women s diseases  
The aim of the study was evaluation the efficiency of essential phospholipids for the treatment of drug-induced liver disease in pregnant women. In the research group included 67 pregnant women with clinical and biochemical manifestations of drug-induced cytolytic syndrome, 58 pregnant women (the main group) were treated with hepatoprotectors, 9 women (the control group) the treatment of essential phospholipids wasn't carried out. Patients of both groups were eliminated hormonal drugs and other
more » ... nal drugs and other drugs or their dosage is reduced as much as possible. Drug liver disease in pregnancy is manifested by increased transaminase, in some cases accompanied by increased level of gamma glutamyl transpeptidase, liver glutamate dehydrogenase. Against the background of the treatment in both groups decrease in transaminases have been reported. But the rate of decline of aminotransferases was differed, so in the main group decrease of ALT and AST was occurred faster than in the control group.
doi:10.17816/jowd66214-23 fatcat:c26zfh6n2bauzj4vb3sbbdvqbi