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Synthesis and antimicrobial evaluation of some new pyrimidines and condensed pyrimidines
2017
Arabian Journal of Chemistry
The reaction of 4-(4-chlorophenyl)-2-mercapto-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 1 with benzylidenemalononitrile and/or methyl iodide has yielded dihydropyrimido[1,2a]pyrimidine derivative 5 and methylthio derivative 6 respectively. Thiated product 7 was cyclized with chloroacetonitrile to give thienopyrimidine derivative 9. Compound 6 was reacted with hydrazine hydrate to give diaminopyrimidine derivative 10. Reaction of 10 with different reagents afforded tetrazolopyrimidine,
doi:10.1016/j.arabjc.2013.11.025
fatcat:jae6te7ejnenpcxe2v7bsd52ha