Synthesis and antimicrobial evaluation of some new pyrimidines and condensed pyrimidines

Essam Abdelghani, Said Aly Said, M.G. Assy, Atef M. Abdel Hamid
2017 Arabian Journal of Chemistry  
The reaction of 4-(4-chlorophenyl)-2-mercapto-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 1 with benzylidenemalononitrile and/or methyl iodide has yielded dihydropyrimido[1,2a]pyrimidine derivative 5 and methylthio derivative 6 respectively. Thiated product 7 was cyclized with chloroacetonitrile to give thienopyrimidine derivative 9. Compound 6 was reacted with hydrazine hydrate to give diaminopyrimidine derivative 10. Reaction of 10 with different reagents afforded tetrazolopyrimidine,
more » ... yrimidine, triazolopyrimidine and pyrimidotriazepine derivatives 11-22. The antimicrobial activity was studied against examples of Gram-positive and Gram-negative bacteria using Tetracycline (Antibacterial agent) and Amphotericin B (Antifungal agent) as standard.
doi:10.1016/j.arabjc.2013.11.025 fatcat:jae6te7ejnenpcxe2v7bsd52ha