White Matter Lesions Are Prevalent but Differentially Related With Cognition in Aging and Early Alzheimer Disease

Jeffrey M. Burns, Jessica A. Church, David K. Johnson, Chengjie Xiong, Daniel Marcus, Anthony F. Fotenos, Abraham Z. Snyder, John C. Morris, Randy L. Buckner
2005 Archives of Neurology  
White matter lesions (WMLs) are prevalent in nondemented aging and in Alzheimer disease (AD). Their relationship with cognition in the earliest stages of AD is unknown. Objective: To assess the relationship between WMLs and cognition in nondemented aging and in early-stage AD. Design: Cross-sectional study. Participants: Participants were nondemented (n=88) or had very mild (n = 48) or mild (n = 20) AD. Main Outcome Measures: Regression coefficients for deep WMLs and periventricular WMLs
more » ... ) as predictors of cognition, after controlling for age, educational achievement, brain atrophy, and infarctlike lesions. Results: White matter lesions were present in nonde-
doi:10.1001/archneur.62.12.1870 pmid:16344345 fatcat:sarj6cs2avbf7gwvgm5ykeiqmi