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White Matter Lesions Are Prevalent but Differentially Related With Cognition in Aging and Early Alzheimer Disease
Archives of Neurology
White matter lesions (WMLs) are prevalent in nondemented aging and in Alzheimer disease (AD). Their relationship with cognition in the earliest stages of AD is unknown. Objective: To assess the relationship between WMLs and cognition in nondemented aging and in early-stage AD. Design: Cross-sectional study. Participants: Participants were nondemented (n=88) or had very mild (n = 48) or mild (n = 20) AD. Main Outcome Measures: Regression coefficients for deep WMLs and periventricular WMLsdoi:10.1001/archneur.62.12.1870 pmid:16344345 fatcat:sarj6cs2avbf7gwvgm5ykeiqmi