PO-0909: Dose and volume effects of gastrointestinal toxicity during neoadjuvant IMRT for rectal cancer

A.L. Appelt, I.R. Vogelius, A. Jakobsen
2015 Radiotherapy and Oncology  
S470 3rd ESTRO Forum 2015 regression and the Area Under the Receiver Operating Curve (A z )). Results: Of three distinct symptom groups identified in all cohorts, labelled Erectile dysfunction (ED), Orgasm dysfunction, and Pain, dose to CC, PB, and CC+PB was associated (p≤0.05) with symptoms in ED. For the EBRT cohort, prediction of any ED symptom/symptoms was the highest with CC D max (A z =0.83; p=0.002). Weaker, but still significant, relationships were found also with CC+PB and PB D max ,
more » ... PB and PB D max , as well as with CC+PB D mean (A z =0.72-0.74; p=0.02-0.04). For the POSTOP cohort, CC and CC+PB D mean predicted one ED symptom (A z =0.65-0.66; 0.02-0.03). Conclusions: Based on patient-reported symptoms on sexual dysfunction from two cohorts, our results suggest that dose to the corpora cavernosa, alone or in combination with the penile bulb may be critical for erectile dysfunction following EBRT for localized prostate cancer. By uncovering the interactions between symptoms as well as how they can be explained by dose to the investigated structures, our findings have the potential to contribute to a better understanding of the underlying radiation-induced causes for sexual dysfunction. PO-0909 Dose and volume effects of gastrointestinal toxicity during neoadjuvant IMRT for rectal cancer
doi:10.1016/s0167-8140(15)40901-6 fatcat:fhnruqmc65fojf3k5oju7cjczy