This document summarises comparative genomics, encompassing phylogenetics, phylogenomics, pangenomics, tools and methodologies, how the Australian life science research community currently undertakes this work as well as common data-, software- or compute-related infrastructure challenges faced by that community when using current approaches (information obtained through consultation with a 'Special Interest Group' (SIG) of researchers undertaking comparative genomics across Australia). Also

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... luded is a high level description of key components of an envisaged shared infrastructure for Australia, which, when implemented, would enable Australian researchers from a wide range of institutions to perform comparative genomics work who would otherwise be unable to do so because of the reported data-, software- or compute-related roadblocks. This document has incorporated feedback from the Comparative Genomics SIG, other Australian researchers undertaking microbiome analysis, international experts undertaking similar work, and numerous Australian research IT infrastructure partners. Implementation of some of the infrastructure outlined in this roadmap document began in 2021, and will continue through 22-23.