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It is clear that OA is a complex multifactorial disease process involving cartilage catabolism and anabolism. LIPUS may play a potential chondroprotective role in chondrocyte metabolism; enhance cell proliferation and matrix production. Aim of Study: Is to investigate the effect of Low Intensity Pulsed Ultrasound (LIPUS) therapy on cartilage repaire in patient with grade 2 or 3 osteoarthritis of the knee. Methods: Subjects were assigned in one pre and post study groupand receive 20 minutes ofdoi:10.21608/mjcu.2019.65656 fatcat:ng6ruirzuvb2fpdaw74rioo6p4